Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma (Running title: Runx1 deficiency and lymphoma)
نویسندگان
چکیده
Genetics and Molecular Biology Branch, Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD; Department of Biochemistry, Dartmouth Medical School, Hanover, NH; Division of Veterinary Resources, Office of Research Services, National Institutes of Health, Bethesda, MD. M.K. is a recipient of a Damon-Runyon Cancer Research Fund Fellowship Award.
منابع مشابه
A Double Negative Loop Comprising ETV6/RUNX1 and MIR181A1 Contributes to Differentiation Block in t(12;21)-Positive Acute Lymphoblastic Leukemia
Childhood acute lymphoblastic leukemia (ALL) with t(12;21), which results in expression of the ETV6/RUNX1 fusion gene, is the most common chromosomal lesion in precursor-B (pre-B) ALL. We identified 17 microRNAs that were downregulated in ETV6/RUNX1+ compared with ETV6/RUNX1- clinical samples. Among these microRNAs, miR-181a-1 was the most significantly reduced (by ~75%; P < 0.001). Using chrom...
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